I've meaning to write a "COVID endgame" thread for a while and I apologize this is somewhat delayed compared to media interviews like and and to recent seminars like 1/17

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Great thread with a "best guess" from @trvrb on where post-pandemic (endemic) burden of COVID may end up. Note: how the virus evolves is one factor, but so is the host (us!) immune response once it's no longer novel. Also: even smaller risk can, at scale, add substantial burden.