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Empire of Pain: The Secret History of the Sackler Dynasty Hardcover – April 13, 2021

4.7 4.7 out of 5 stars 11,882 ratings

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NEW YORK TIMES BESTSELLER • A NEW YORK TIMES NOTABLE BOOK OF THE YEAR • A grand, devastating portrait of three generations of the Sackler family, famed for their philanthropy, whose fortune was built by Valium and whose reputation was destroyed by OxyContin. From the prize-winning and bestselling author of Say Nothing.

"A real-life version of the HBO series Succession with a lethal sting in its tail…a masterful work of narrative reportage.” – Laura Miller, Slate

The history of the Sackler dynasty is rife with drama—baroque personal lives; bitter disputes over estates; fistfights in boardrooms; glittering art collections; Machiavellian courtroom maneuvers; and the calculated use of money to burnish reputations and crush the less powerful. The Sackler name has adorned the walls of many storied institutions—Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, but the source of the family fortune was vague—until it emerged that the Sacklers were responsible for making and marketing a blockbuster painkiller that was the catalyst for the opioid crisis.

Empire of Pain is the saga of three generations of a single family and the mark they would leave on the world, a tale that moves from the bustling streets of early twentieth-century Brooklyn to the seaside palaces of Greenwich, Connecticut, and Cap d’Antibes to the corridors of power in Washington, D.C. It follows the family’s early success with Valium to the much more potent OxyContin, marketed with a ruthless technique of co-opting doctors, influencing the FDA, downplaying the drug’s addictiveness. Empire of Pain chronicles the multiple investigations of the Sacklers and their company, and the scorched-earth legal tactics that the family has used to evade accountability.

A masterpiece of narrative reporting,
Empire of Pain is a ferociously compelling portrait of America’s second Gilded Age, a study of impunity among the super-elite and a relentless investigation of the naked greed that built one of the world’s great fortunes.
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Popular Highlights in this book

From the Publisher

engrossing says the new york times

explosive says the washington post

he's a national treasure says rachel maddow

novelistic says the boston globe

2021 accolades

real life succession

Editorial Reviews

Review

New York Times Book Review 100 Notable Books of the Year • One of The Washington Post's 10 Best Books of the Year TIME Magazine 100 Must Read Books of 2021 One the Best Books of the Year: NPR, Slate, EW, Boston Globe, Goodreads, The Guardian, Town & Country, BuzzFeed, LitHub, Vulture, and more

Winner of the Baillie Gifford Prize for Non-Fiction and Finalist for the Baillie Gifford Winner of Winners Award

One of President Obama's Favorite Books of the Year


“An engrossing (and frequently enraging) tale of striving, secrecy and self-delusion….Keefe nimbly guides us through the thicket of family intrigues and betrayals… Even when detailing the most sordid episodes, Keefe’s narrative voice is calm and admirably restrained, allowing his prodigious reporting to speak for itself. His portrait of the family is all the more damning for its stark lucidity.” —
Jennifer Szalai, The New York Times
 
“I read everything he writes. Every time he writes a book, I read it. Every time he writes an article, I read it … he’s a national treasure.” —
Rachel Maddow, host of MSNBC’s “The Rachel Maddow Show” and author of the #1 New York Times bestselling Blowout

“A true tragedy in multiple acts. It is the story of a family that lost its moorings and its morals… Written with novelistic family-dynasty and family-dynamic sweep, EMPIRE OF PAIN is a pharmaceutical FORSYTHE SAGA, a book that in its way is addictive, with a page-turning forward momentum.”  —
David M. Shribman, The Boston Globe
 
“A brutal, multigenerational treatment of the Sackler family… Keefe deepens the narrative by tracing the family's ambitions and ruthless methods back to the founding patriarch, Arthur Sackler…His life might be a model for the American dream, if it hadn't arguably laid the foundations for a still-unfolding national tragedy.”  —
Brian Mann, NPR.org
 
“The opioid epidemic has killed nearly half a million Americans over the past two decades. Many of their loved ones, along with public health advocates and experts, believe that one very rich, very famous family has never fully faced the consequences for its role in those deaths. EMPIRE OF PAIN, the explosive new book by journalist Patrick Radden Keefe, is an attempt to change that — to hold the family accountable in a way that nobody has quite done before, by telling its story as the saga of a dynasty driven by arrogance, avarice and indifference to mass suffering…. Keefe marshals a large pile of evidence and deploys it with prosecutorial precision.   Keefe is a gifted storyteller who excels at capturing personalities.” —
Jonathan Cohn, The Washington Post

"Keefe has a way of making the inaccessible incredibly digestible, of morphing complex stories into page-turning thrillers, and he's done it again with Empire of Pain…A scathing — but meticulously reported — takedown of the extended family behind OxyContin, widely believed to be at the root cause of our nation's opioid crisis.  It's equal parts juicy society gossip and historical record of how they built their dynasty and eventually pushed Oxy onto the market.”  —
Seija Rankin, Entertainment Weekly
 
 “An air-tight indictment of the family behind the opioid crisis….[an] impressive exposé.” —
Harriet Ryan, The Los Angeles Times

“A damning portrait of the Sacklers, the billionaire clan behind the OxyContin epidemic. If you are someone who engages in this kind of sneaky conduct, the last person you want reporting on you is Keefe….[He] has a knack for crafting lucid, readable descriptions of the sort of arcane business arrangements the Sacklers favored. He is also indefatigable….The Sackler infighting described in
Empire of Pain will surely prompt many comparisons to the HBO series Succession.”Laura Miller, Slate

"One of the Ten Best Books of 2021"
Laura Miller, Slate

“Put simply, this book will make your blood boil….a devastating portrait of a family consumed by greed and unwilling to take the slightest responsibility or show the least sympathy for what it wrought….a highly readable and disturbing narrative.” —
John Carreyrou, The New York Times Book Review (cover)
 
“Rigorously reported and brilliantly executed Empire of Pain hones in on the family whose company developed, unleashed, and pushed the drug on Americans, pulling in billions of dollars for themselves in the process….This is an important, necessary book.” - Hillary Kelly, New York magazine

“A shocking saga… [a]tour-de-force account… [Keefe] brings to life the obsessive personalities and ferocious energy of some members…The Sacklers emerge as a shameless bunch, but
Empire of Pain also poses troubling questions about the US healthcare system that permitted them to flourish.” —John Gapper,The Financial Times

"Empire of Pain reads like a real-life thriller, a page-turner, a deeply shocking dissection of avarice and calculated callousness… It is the measure of great and fearless investigative writing that it achieves retribution where the law could not….Exhaustively researched and written with grace and gravity, Empire of Pain unpeels a most terrible American scandal. You feel almost guilty for enjoying it so much."  —The Times (London)

"Indefatigable investigative journalist Keefe crafts a page-turning corporate biography and jaw-dropping condemnation of the Sacklers’ amoral disregard for anything save the acquisition of power, privilege, and influence. In Keefe’s expert hands, the Sackler family saga becomes an enraging exposé of what happens when utter devotion to the accumulation of wealth is paired with an unscrupulous disregard for human health." —
Carol Haggas, Booklist

“An engrossing and deeply reported book about the Sackler family, the owners of Purdue Pharma. Their company created Oxycontin, the opioid introduced in the mid-90s that sent a wave of addiction and death across the country. Unlike previous books on the epidemic,
Empire of Pain is focused on the wildly rich, ambitious and cutthroat family that built its empire first on medical advertising and later on painkillers. In his hands, their story becomes a great American morality tale about unvarnished greed dressed in ostentatious philanthropy.” —Time Magazine, The Best Books of 2021 So Far

About the Author

Patrick Radden Keefe is a staff writer at The New Yorker  and the author, most recently, of the New York Times bestseller Say Nothing: A True Story of Murder and Memory in Northern Ireland, which received the National Book Critics Circle Award for Nonfiction, was selected as one of the ten best books of 2019 by The New York Times Book Review, The Washington Post, the Chicago Tribune and The Wall Street Journal, and was named one of the “10 Best Nonfiction Books of the Decade” by Entertainment Weekly. His previous books are The Snakehead and Chatter. His work has been recognized with a Guggenheim Fellowship, the National Magazine Award for Feature Writing and the Orwell Prize for Political Writing. He is also the creator and host of the eight-part podcast Wind of Change.

Product details

  • Publisher ‏ : ‎ Doubleday; First Edition (April 13, 2021)
  • Language ‏ : ‎ English
  • Hardcover ‏ : ‎ 560 pages
  • ISBN-10 ‏ : ‎ 0385545681
  • ISBN-13 ‏ : ‎ 978-0385545686
  • Item Weight ‏ : ‎ 1.95 pounds
  • Dimensions ‏ : ‎ 6.3 x 1.5 x 9.3 inches
  • Customer Reviews:
    4.7 4.7 out of 5 stars 11,882 ratings

About the author

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Patrick Radden Keefe
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Patrick Radden Keefe is an award-winning staff writer at The New Yorker and the bestselling author of five books, including Empire of Pain: The Secret History of the Sackler Dynasty, which received the Baillie Gifford Prize for Nonfiction and was a finalist for the FT Business Book of the Year, and Say Nothing: A True Story of Murder and Memory in Northern Ireland, which received the National Book Critics Circle Award. His most recent book is Rogues: True Stories of Grifters, Killers, Rebels and Crooks. The recipient of the National Magazine Award for Feature Writing and the Orwell Prize for Political Writing, he is also the creator and host of the 8-part podcast "Wind of Change," about the strange intersection of Cold War espionage and heavy metal music, which was named the #1 podcast of 2020 by Entertainment Weekly and the Guardian and has been downloaded more than 10 million times. He grew up in Boston and now lives in New York.

Customer reviews

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Top reviews from the United States

Reviewed in the United States on January 4, 2024
The story of Oxycontin is a tale of staggering greed, mendacity, and maleficence, one that spans decades. This tale is masterfully told in Patrick Keefe’s Empire of Pain.

Oxycontin was the sole product of Purdue Pharma, a spinoff of small company acquired by the Sackler brothers — Arthur, Raymond, and Mortimer — which subsequently morphed into an industry giant.

Wisely, Keefe begins at the beginning, with the story of Arthur, the eldest Sackler brother. Arthur died ten years before Oxycontin was introduced, but it was he who created a system that made drug wrecks like Oxycontin inevitable. This was not a man who wished to do well by doing good. Rather, this was a man obsessed with achieving a totalitarian level of control over drug information, with the seamless vertical integration of drug development, clinical trials, scientific journals, and marketing — all with Arthur Sackler pulling the strings from behind the scenes. Indeed, every play in the Oxycontin playbook could have been taken from Sackler’s campaign to market Pfizer’s blockbuster drugs Librium and Valium — the marketing of dangerous, highly addictive drugs for a dizzying variety of human woes (without any good data showing their effectiveness), the pious insistence that these drugs were not addictive, and — when this point was decisively refuted — the blaming and stigmatizing of addicts for their plight.

As the country was flooded with Oxycontin, and doctors were flooded with false and misleading information about the safety and effectiveness of Purdue Pharma’s blockbuster drug, overdose deaths skyrocketed. Meanwhile, the Sacklers purchased a veneer of respectability by donating millions of dollars to museums, art galleries, and universities — a small price to pay, given that the drug netted them billions. Even as the death toll mounted, the Sacklers stubbornly refused to diversify, preferring to treat the company as their private ATM.

Purdue Pharma declared bankruptcy in September of 2021, but by then the company was little more than an empty shell — the Sacklers had already drained the company coffers dry, and the bankruptcy settlement guaranteed they will keep almost all of the billions they siphoned off. Fines to the Sacklers and their ilk are as seizures are to the cocaine lords — part of the cost of doing business.

This book makes for gripping reading, but even more importantly it highlights the need for criminal prosecution for drug company execs who flout the law. Nothing else will do.
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Reviewed in the United States on December 28, 2023
The death toll from OxyContin, a strong opiate based painkiller like fentanyl, and have been the source of epidemic level addiction, and hundreds of thousands of deaths have been attributed to its abuse. This book is about OxyContin, which, at its height, was the best-selling painkiller. The book, ‘Pain Killer’ by Meier, and the Netflix movie based on it, shows graphically how that drug became pervasive in the USA.

This book by Keefe, goes behind the scene, to study the family behind the OxyContin miracle product and the billions of dollars that drug generated for the family. The head was the eldest of three Sackler brothers – Arthur, Mortimer, and Raymond. Keefe traces the roots of Arthur Sackler’s career, and how he brought his brothers, and a fourth man, Bill Frolich together in the drug (and related) ventures. They became known as the Four Musketeers.

Like ‘Pain Killer’, Richard Sackler, son of Raymond Sackler, was a principal character in pushing OxyContin from the factories to the streets, through hospitals and clinics. Richard, when confronted, just like his cousin Kathe, denied full knowledge. Senator Peter Welch stated, ‘El Chapo got a life sentence, and he is going to forfeit his $12 billion…The Sackler family through Purdue has three felony convictions, but no one is going to jail, and it has its billions still’. Kathe, Richard Sackler’s cousin, retorted, ‘Excuse me, the Sackler family doesn’t have a felony conviction. Purdue Pharma has a felony conviction. I am an individual person.’ But when asked if she would have done anything differently, knowing what then what she now knew, she said, ‘No’.

The thrust of the book is about the blowup from the scandal, and how the Sackler family settled the suit against them. Had they won? Was justice done for all the victims of OxyContin? The answer is still in the air as the Supreme Court has put the settlement on hold till 2024.

The underlying theme of this book is about the version of capitalism that enables people like to Sacklers to enrich themselves at the expense of the poor and the ignorant. It is also about how the national healthcare system failed to arrest the problem of addiction.
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Reviewed in the United States on February 12, 2024
Very interesting read. Be prepared to learn some new words!!! A very well written, well researched saga of a sad but true telling of how much power the all might dollar wields.
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Top reviews from other countries

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Orlando Cucolo Jr
5.0 out of 5 stars Engaging read, a truly 5-star book!
Reviewed in Brazil on January 27, 2024
“I started reading Patrick Radden Keefe due to the book ‘Say Nothing’ about IRA activities in Northern Ireland. Subsequently, I read ‘Empire of Pain,’ detailing how the Sackler family, posing as philanthropists, contributed to the opioid epidemic in the USA. They aggressively promoted OxyContin through Purdue Pharma reps, encouraging doctors to prescribe this highly addictive painkiller, containing oxycodone, a semi-synthetic derivative of opium. The book reveals the deceptive promotion, leading to widespread addiction and the destruction of lives and families over the past 30 years in the USA and beyond. Engaging read, a truly deserving 5-star book!”
Ana A
5.0 out of 5 stars Informativo y como novela
Reviewed in Mexico on April 2, 2022
Excelente prosa e investigación. Se lee como novela.

Habla del 1) origen de la epidemia de opiáceos con un fármaco autorizado el OXYCONTIN,
2) del margen en el sistema regulador estaudinense que permitió la venta de un medicamento altamente ADICTIVO y
3) de un sistema de justicia deficiente que no ha podido llevar ante la justicia a la familia responsable de esa epidemia. Imponiendo tan sólo multas que aunque billonarias están tan espaciadas en el tiempo que no afectan en nada la fortuna de esos empresarios
ellen roseman
5.0 out of 5 stars An indictment of the capitalist system
Reviewed in Canada on February 28, 2022
This book made me furious. How did the Sackler family make so much money on powerful drugs that addicted or killed people without being held accountable? How could they hold themselves out as innocent, despite the mounting evidence, and never give interviews or express any sorrow for the victims?

The author makes the same points again and again, using examples of other large U.S. companies that got away with the same legal manoeuvres. But the Sacklers did it for three generations!

Their continued lying and blaming overdose deaths on the “junkies” who misused the medication — and their false claims of having nothing to do with Purdue’s operations, even though eight family members sat on the board at one time and micromanaged every move that executives made — becomes excruciatingly hard to stomach as a reader.

This book is the first to pin down the Sacklers’ culpability for crimes committed over the years without any consequences except a penalty payment of $225 million, despite their removal of billions of dollars from Purdue before its bankruptcy.

You may need a Valium (a drug launched by Arthur Sackler, the patriarch and master pill pusher) to soldier through to the end of this incendiary story. I had to take many breaks.

But I’m grateful to Patrick Raden Keefe for telling the world how this unrepentant family hurt so many sick people by using high pressure and lucrative incentives to persuade doctors to prescribe OxyContin. They did so without a shred of concern for those who died while taking it according to the written instructions.

Not only did Purdue keep committing the same crimes with impunity, but it taught other drug makers to use the same marketing tactics geared to excessive profits. And, alas, the death count of the opioid crisis will continue.
3 people found this helpful
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Badabimbadabum
5.0 out of 5 stars Good read
Reviewed in Germany on March 28, 2024
Well written, informative and interesting.
Mikael Kjellberg
5.0 out of 5 stars Omfattande men lättläst
Reviewed in Sweden on March 25, 2024
Mycket bra bok, verkligen omfattande och förstås skrämmande utifrån läkemedelsföretag, godkännande process samt läkarnas påverkan....