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Heraclitean Fire: Sketches from a Life Before Nature

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The eminent biochemist reflects on his life and work in Vienna and in America, shedding light on his DNA research and the work and opinions that led to his reputation as a maverick.

252 pages, Hardcover

First published June 1, 1978

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About the author

Erwin Chargaff

39 books4 followers
Erwin Chargaff was an Austrian biochemist who was a professor of biochemistry at Columbia University medical school.
Chargaff proposed main rules in his lifetime related to DNA studies best known as Chargaff's Rules.

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Displaying 1 - 8 of 8 reviews
Profile Image for Audrey.
329 reviews39 followers
December 25, 2012
I'd tap that.

Did biochemist Erwin Chargaff, of the famous "Chargarff's rules" originally write his memoir in German? If this is the case, I will cut him some slack for writing in the kind of way I have very little patience for - overwrought, melodramatic, and earnest. Imagine reading Frasier Crane or Ignatius Reilly's memoirs and you have Heraclitean Fire.

Chargaff actually complains at one point "purple" language is frowned upon and how English is not a language for celebrating language. Well, not if it comes out like this.

I mainly picked up this book because I wanted to read bitchy, bitter things about Watson and Crick. Chargaff did not disappoint on that front.

p. 101-102:

The impression: one, thirty-five years old; the looks of a fading racing tout, something out of Hogarth ("The Rake's Progress"); Cruikshank, Daumier; an incessant falsetto, with occasional nuggets glittering in the turbid stream of prattle. The other, quite undeveloped at twenty-three, a grin, more sly than sheepish; saying little, nothing of consequence; a "gawky young figure, so reminiscent of one of the apprentice cobblers out of Nestroy's Lumpazivagabundis." I recognized a variety act, with the two partners at the time showing excellent teamwork, although in later years helical duplicity diminished considerably. The repertory was, however, unexpected. [...]

It was clear to me that I was faced with a novelty: enormous ambition and aggressiveness, coupled with an almost complete ignorance of, and a contempt for, chemistry, that most real of exact sciences - a contempt that was later to have a nefarious influence on the development of "molecular biology."


Here's an excerpt in that Chargaff explains how he feels, getting shafted from the glory: p 103

When the Artemision - one of the world wonders of antiquity - went up in flames in 356 B.C., a man was apprehended who confessed that he had done it in order to make his name immortal. The judges, in condemning him, decreed that his name must remain unknown. But soon after, the historian Theopompos claimed that the name was Herostratos. Whether this really was the name or whether Theopompos merely wanted to annoy, say, his father-in-law, cannot be ascertained. Recently, when I mentioned Herostratos in an article, the editor called up to say that nobody in the editorial office had ever heard of him, thus giving belated satisfaction to the judges of Ephesos.
If Herostratos has earned immortality for having burned down the temple of Artemis of Ephesos, maybe the man from whom he got ht matches ought not to be entirely forgotten. I am that man.


It is kind of sad to read that instead of wonder at all of the discoveries that had been made in the fields of molecular biology and cell biology, Chargaff felt only alienation from practicing science (and from his colleagues) and grim forebodings about the implications of biotechnology.

But back to the bitchy things!
p 156-157:

What is science? Truly a big question about which large books have been written that I have great difficulty in reading. I shall give a simple answer. Science is the attempt to learn the truth about those parts of nature that are explorable. Science, therefore, is not a mechanism to explore the unexplorable; and it is not its task to decide on the existence or nonexistence of God or to measure the weight of a soul. It is very unfortunate that science has become extremely arrogant - this started at the time of Darwin, but is getting worse - and that scientists arrogate to themselves a special right to speak out loudly, and often stupidly, on almost any topic. For instance, the National Academy of Sciences, which is, after all, only a sort of chamber of scientific commerce into which some very funny characters have entered through various backdoors, is widely regarded as the true receptacle of wisdom. But when you spend your life watching a bubble chamber or running cesium chloride gradients you may become an expert bubble or gradient runner, but there is little likelihood of your thus acquiring much wisdom. There is, in fact, a good chance that such people will turn into very dull fellows indeed, wasting their lives by trying to outrun ten other dull fellows with whom they are in competition.


As a (relatively) young person with hopes of pursuing a PhD in biology, it is interesting to read some of the sad but eerily prophetic things Chargaff had to say about the state of science research in academia, with the constant pressure to publish ("publish or perish!") and the constant pressure to get funding when the sources of funding are shrinking every year. (This book was published in 1978). p 162-163

Our kind of science has become so dependent on public support that nobody seems to be able to do any research without a handout. If their applications are turned down, even the youngest and most vigorous assistant professors stop all work and spend the rest of their miserable days writing more applications. This continual turning off and on of the financial faucets produces Pavlovian effects and a general neurasthenia that are bound to damage science irreversibly. It would have been much better if it had never got so rich before getting so poor, for in the meantime many young people have been lured into a career that may never materialize.




Profile Image for Alison.
22 reviews5 followers
March 31, 2018
This poor, bitter man had such a bizarre view of science, esp the biological sciences. There’s almost zero mention of or appreciation for the absolutely massive revolution in medicine, which to most ppl is a cornerstone of biological science. I’m sure it’s a product of the horrible ways he saw science used during WW2, and his points there are well-taken. But unfortunately other than that and a few other minor points, this book didn’t have much perspective to give me about working in science today.
Profile Image for Drew.
366 reviews1 follower
August 14, 2016
Biologist. Brilliant man. Perhaps should have shared the Nobel with Crick and Watson. His findings paved the way for the double helix. Somewhat of a curmudgeon. At one point read in 15 different languages. The book is a memoir. He is pessimistic about the future of humankind and the world. Very interesting read with the most difficult vocabulary I have encountered.
Profile Image for Reinhold.
506 reviews30 followers
December 9, 2008
Erwin Chargaff, der Entdecker der Basenkomplementarität in der DNS, gilt als einer der Urväter der Gentechnik. In seiner Autobiographie aus dem Jahr 1979 rechnet er mit seiner Vergangenheit und der (damaligen) Zukunft der Gentechnik ab. Chargaff erging es somit ähnlich wie Albert Einstein - vergleichbar Goethes Zauberlehrling wurde er die Geister die er rief nicht mehr los. Was er in Bewegung gesetzt hatte entwickelte sich in eine Richtung die er nur mehr ablehnen konnte.

Als einer der wesentlichsten Sätze bleibt hängen: " Zwei verhängnisvolle wissenschaftliche Entdeckungen haben mein Leben gekennzeichnet: erstens die Spaltung des Atoms, zweitens die Aufklärung der Chemie der Vererbung. In beiden Fällen ging es um Misshandlung des Kerns: des Atomkerns, des Zellkerns. In beiden Fällen habe ich das Gefühl, dass die Wissenschaft eine Grenze überschritten hat, die sie hätte scheuen sollen."

Immer wieder kommt der spöttische, bittere und polemische Stil, seines Lehrers und Freundes Karl Kraus durch. Ein technologiekritisches Buch das trotz seines Alters noch immer Gegenwartsbezug hat und durchaus lesenswert ist.
Profile Image for Erik Rostad.
371 reviews142 followers
April 30, 2017
I loved this book. Written by Erwin Chargaff (1905 - 2002), a Columbia University biochemist, it is part autobiography, part critique of modern science (modern from 1978 when it was written). Chargaff is humurous, deep, and challenging. His critique of science is even more prescient today. His wariness of the direction science took began with the dropping of the A-bombs on Japan. I had never heard of Erwin Chargaff or this book, but it was excellent and highly recommended.
100 reviews3 followers
July 28, 2018
A very good autobiography of one of the founders of modern molecular biology. In the old style, this is an introspective journey through a life looking both forward and backward. Liberally interspersed with references to art, music, and literature in the cultured European style, it is a welcome change from the current style of "reporting" a life. Lots to ponder!! FYI...out of print
December 30, 2018
Most of the time, this book is just a pretentious critique of half a century of American academia; while it is far from a perfect entity, the contents of this autobiography are bitter and almost never justified. With that being said, the conclusion is touching, and reveals a love for biology and science in general that surpasses the failure to understand its evolution.
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